Thy1-positive mesenchymal cells promote the maturation of CD49f-positive hepatic progenitor cells in the mouse fetal liver
نویسندگان
چکیده
منابع مشابه
Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells.
We previously reported that the in vitro maturation of CD49f(+)Thy1(-)CD45(-) (CD49f positive) fetal hepatic progenitor cells (HPCs) is supported by Thy1-positive mesenchymal cells derived from the fetal liver. These mesenchymal cell preparations contain two populations, one of a cuboidal shape and the other spindle shaped in morphology. In this study, we determined that the mucin-type transmem...
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Enrichment of hepatic progenitor cells from adult mouse liver.
Hepatic progenitor cells (HPCs) have been characterized in several drug-treated rodent models and in the fetal liver; however, their properties have not been fully clarified in the normal adult liver, presumably because of their relatively small population and the existence of mature hepatocytes. In an attempt to resolve this issue, we developed a new enrichment system for HPCs using their cell...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2004
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.20180